Research & Evidence
Where research meets real-world joint healing.
The Pinnacle Method is built on peer-reviewed research in regenerative orthopedics and joint preservation.Below you’ll find published medical literature supporting PRP, bone marrow concentrate (BMAC), and non-surgical joint care—so you can explore the evidence behind your options.
Subacromial injection of platelet-rich plasma provides greater improvement in pain and functional outcomes compared to corticosteroids at 1-year follow-up: a double-blinded randomized controlled trial
New Study: Exosome Therapy from Umbilical Cord Stem Cells Shows Early Promise for Osteoarthritis
Non-surgical treatment of anterior cruciate ligament tears with percutaneous bone marrow concentrate and platelet products versus exercise therapy: a randomized-controlled, crossover trial with 2-year follow-up
Springer Nature, 2025
Establishing metrics of clinically meaningful change for treating knee osteoarthritis with a combination of autologous orthobiologics
Nature, 2025
Intradiscal Injections of Bone Marrow Concentrate or Leukocyte-Rich Platelet-Rich Plasma for the Treatment of Cervical Discogenic Pain: A Case Series
Cureus, 2025
Percutaneous autologous bone marrow concentrate for knee osteoarthritis: patient-reported outcomes and progenitor cell content
International Orthopaedics, 2022
Evidence-Based Clinical Practice Guidelines on Regenerative Medicine Treatment for Chronic Pain: A Consensus Report from a Multispecialty Working Group
Dovepress, 2024
The rate of venous thromboembolism after knee bone marrow concentrate procedures: should we anticoagulate?
International Orthopaedics, 2022
Percutaneous bone marrow concentrate and platelet products versus exercise therapy for the treatment of rotator cuff tears: a randomized controlled, crossover trial with 2-year follow-up
IBMC Musculoskelet Disord, 2024
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